Why it's Hot:
- 2nd appearance of Curt Connors in human form throughout – does not turn into the Lizard again until The Amazing Spider-Man #44
Synopsis:
As Aunt May's life hangs in the balance due to radioactive particles in her blood, Spider-Man races against time to retrieve the ISO-36 serum needed to save her. His desperate mission leads him to Curt Connors and into conflict with the Master Planner—revealed to be Doctor Octopus. The issue culminates with Spider-Man trapped beneath tons of rubble in a flooding lair, leading into one of the most iconic cliffhangers in comic book history.
